Histamine formation in the blood and bone marrow of the guinea pig

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Abstract
The histamine content and the histidine decarboxylase activity of bone marrow have been studied in guinea pigs treated with foreign protein. In some experiments the effect of 6-methylprednisolone also was observed. Treatment of guinea pigs with foreign protein resulted in a 10-fold increase of both histamine concentration and histidine decarboxylating activity in the blood and bone marrow. Histamine levels and histidine decarboxylating activity were related to the number of basophils. A fairly constant relationship was found between the histamine content and the enzyme activity per basophil. The findings suggest that histamine is formed and to a certain extent also stored in the basophilic leukocytes.