Pulmonary uptake of liposomal phosphatidylcholine upon intratracheal administration to rats.

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Abstract
Liposomes composed of dipalmitoylphosphatidylcholine (DPPC) labeled with L-.alpha.-[dipalmitoyl-1-14C]-phosphatidylcholine ([14C]DPPC) and cholesterol (molar ratio 7:2) were injected into rats intratracheally [to investigate their use in treating neonatal respiratory distress syndrome]. The lungs took up .apprx. 90% of administered [14C]DPPC, and 50% of liposomal DPPC was retained for over 24 h. Uptake by the liver and kidney after i.v. administration was high and uptake by the lung was negligible. Uptake of [14C]DPPC by lung lamellar bodies was higher than that by other lung subcellular fractions (mitochondria, microsomes and soluble fractions). Histochemical investigation showed that the liposomes were taken up uniformly by the lung.

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