DURATION OF LIFE AFTER SUPRARENALECTOMY IN CATS AND ATTEMPTS TO PROLONG IT BY INJECTIONS OF SOLUTIONS CONTAINING SODIUM SALTS, GLUCOSE AND GLYCEROL

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Abstract
The data of 101 "uncomplicated" experiments are summarized. Control cats from which both suprarenals were removed at one operation survived 5.3 days (ave.). The administration of physiological salt solution, Ringer''s solution and isotonic Na acetate solution increased the duration of life to about 3 times that of controls. More concentrated solutions of NaCl shortened life. Isotonic glucose and glycerol solutions had only a slight life-prolonging effect. Diuresis is regarded as an important factor determining the duration of life. When the loss of water by diuresis is compensated by an additional intake, life is prolonged; if not, life is shortened. There is some indication that the loss of Na has a specific influence other than a possible acidosis. It is believed that all the manifestations of suprarenalectomy thus far observed are individual details of a more fundamental and as yet unknown disturbance in nutrition in which the sympathetic nervous system is primarily concerned.

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