Preparation of 3H‐labelled apomorphine, N‐n‐propylnorapomorphine, and O, O‐dipivaloylapomorphine
- 1 January 1979
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 16 (4) , 597-601
- https://doi.org/10.1002/jlcr.2580160412
Abstract
Apomorphine and N‐n‐propylnorapomorphine were tritiated using trifluoroacetic acid‐ tritiated water mixtures. This provides a route to the synthesis of tritiated O,O‐dipivaloylapomorphine. Deuterium exchange and NMR studies indicate that exchange only involves protons at the C‐8 and C‐9 positions.Keywords
This publication has 9 references indexed in Scilit:
- Schizophrenic Symptoms Improve with ApomorphineScience, 1978
- Gas chromatographic determination of apomorphine in plasmaJournal of Chromatography A, 1977
- Prolonged apomorphine-like behavioural effects of apomorphine estersNeuropharmacology, 1976
- Diester derivatives as apomorphine prodrugsJournal of Medicinal Chemistry, 1976
- Treatment of Parkinson's Disease with AporphinesNew England Journal of Medicine, 1976
- Apomorphine in huntington's chorea: Clinical observations and theoretical considerationsLife Sciences, 1974
- Synthesis of tritium- and deuterium-labeled apomorphineJournal of the American Chemical Society, 1973
- BLOCKADE BY APOMORPHINE OF HALOPERIDOL-INDUCED DYSKINESIA IN SCHIZOPHRENIC PATIENTSThe Lancet, 1972
- A Rapid and Sensitive Method of Quantitative Determination of Apomorphine**University of California School of Pharmacy and Department of Pharmacology, School of Medicine, San Francisco 22Journal of the American Pharmaceutical Association (Scientific ed.), 1959