Elaboration of Collagen Precursors By Osteoblasts in Rat Alveolar Bone As Visualized By Electron Microscope Radioautography
- 1 August 1973
- journal article
- Published by Cambridge University Press (CUP) in Proceedings, annual meeting, Electron Microscopy Society of America
- Vol. 31, 346-347
- https://doi.org/10.1017/s0424820100072174
Abstract
Recent studies, reviewed by Grant and Prockop, have provided evidence for an intracellular form of collagen referred to as "procollagen". This molecule is similar to the rod-like tropocollagen molecule except for the presence of a 13nm terminal piece. The conversion of procollagen to tropocollagen by cleavage of the terminal piece is believed to take place extracellularly. Fine structural studies on odontoblasts, the cells which secrete the collagen of dentin matrix, indicate that filamentous structures, interpreted as procollagen, are condensed into secretory granules in the Golgi apparatus, transported to their sites of secretion in the odontoblast process and released to the cell surface by exocytosis. To determine whether similar events occur in osteoblasts, the elaboration of collagen by these cells was investigated using radioautography and electron microscopy.This publication has 1 reference indexed in Scilit:
- A SEMIAUTOMATIC INSTRUMENT FOR THE RADIOAUTOGRAPHIC COATING TECHNIQUEJournal of Histochemistry & Cytochemistry, 1966