Asbestos bodies in bronchoalveolar lavage fluids of brake lining and asbestos cement workers.
- 1 February 1990
- journal article
- research article
- Published by BMJ in Occupational and Environmental Medicine
- Vol. 47 (2) , 91-98
- https://doi.org/10.1136/oem.47.2.91
Abstract
Asbestos body (AB) concentrations in bronchoalveolar lavage samples of 15 brake lining (BL) workers exposed only to chrysotile have been determined and compared with those from 44 asbestos cement (AC) workers extensively exposed to amphiboles. The mean AB concentrations (263 .+-. 802 and 842 .+-. 2086 AB/ml respectively) for those groups did not differ significantly but were much higher than those found in control groups. Analytical electron microscopy of asbestos body cores showed that in the BL group 95.6% were chrysotile fibres whereas in the AC group amphiboles accounted for 93.1%. The size characteristics of the central fibres differed for chrysotile and amphibole AB, the former being shorter and thinner. Examination of repeated bronchoalveolar lavage samples showed that the mechanisms of clearance of chrysotile fibres do not affect AB concentration for at least 10 months after cessation of exposure. It thus appears that routine counting of ABs in BAL allows the assessment of current or recent occupational exposures to asbestos. Exposures to chrysotile lead to AB concentrations comparable with those encountered in exposures to amphiboles.This publication has 26 references indexed in Scilit:
- Object‐marking, a bridge between light and analytical electron microscopy for particles characterizationJournal of Electron Microscopy Technique, 1988
- Mineral fibres and mesothelioma.Thorax, 1986
- Asbestos fibres in bronchoalveolar lavage fluid from asbestos workers: examination by electron microscopy.Occupational and Environmental Medicine, 1986
- Asbestos bodies and the diagnosis of asbestosis in chrysotile workersEnvironmental Research, 1986
- Fiber size and number in workers exposed to processed chrysotile asbestos, chrysotile miners, and the general populationAmerican Journal of Industrial Medicine, 1986
- Asbestos content of lung tissue in asbestos associated diseases: a study of 110 cases.Occupational and Environmental Medicine, 1985
- The enigmatic asbestos body: Its formation and significance in asbestos-related diseaseEnvironmental Research, 1985
- Fibre type and concentration in the lungs of workers in an asbestos cement factory.Occupational and Environmental Medicine, 1983
- Concentrations and dimensions of coated and uncoated asbestos fibres in the human lung.Occupational and Environmental Medicine, 1980
- Asbestos bodies, their formation, composition and characterEnvironmental Research, 1972