HISTAMINASE IN THE TREATMENT OF HAY FEVER

22 June 1940

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 114 (25) , 2448-2449
https://doi.org/10.1001/jama.1940.02810250022005

Abstract

Best¹demonstrated, from the results of in vitro experiments, that a histamine inactivating substance existed. Later Best and McHenry²proved the specificity of this inactivating substance for histamine and accordingly suggested that the inactivating substance be known as histaminase. Histaminase has now become a popular drug for clinical experimentation in allergic diseases and allied disorders. The foundation for this clinical experimentation is based entirely on the hypothetical assumption that the allergic reaction is caused by the liberation of "H-substance" at the site of contact of antibody with antigen and on the probability that histaminase might inactivate the "H-substance," which is similar but not identical to histamine. Histaminase has been reported to be effective in the treatment of hay fever,³urticaria,⁴angioneurotic edema,⁵allergic eczema,⁶seborrheic eczema,⁵acne vulgaris,⁷Ménière's disease,⁵gastrointestinal allergy,⁸ulcerative colitis,⁹cold allergy¹⁰and serum

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