Homologues of 26S proteasome subunits are regulators of transcription and translation
Open Access
- 1 May 1998
- journal article
- for the-record
- Published by Wiley in Protein Science
- Vol. 7 (5) , 1250-1254
- https://doi.org/10.1002/pro.5560070521
Abstract
Single copies of an α-helical-rich motif are demonstrated to be present within subunits of the large multiprotein 26S proteasome and eukaryotic initiation factor-3 (eIF3) complexes, and within proteins involved in transcriptional regulation. In addition, p40 and p47 subunits of eIF3 are shown to be homologues of the proteasome subunit Mov34, and transcriptional regulators JAB1/pad1. Finally, the proteasome subunit S5a and the p44 subunit of the basal transcription factor IIH (TFIIH) are identified as homologues. The presence of homologous, and sometimes identical, proteins in contrasting functional contexts suggests that the large multisubunit complexes of the 26S proteasome, eIF3 and TFIIH perform overlapping cellular roles.Keywords
This publication has 49 references indexed in Scilit:
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory proteinThe EMBO Journal, 1997
- cDNA Cloning of p40, a Regulatory Subunit of the Human 26S Proteasome, and a Homolog of the Mov-34 Gene ProductBiochemical and Biophysical Research Communications, 1995
- Subunits of the regulatory complex of the 26S proteaseMolecular Biology Reports, 1995
- Maximum Discrimination Hidden Markov Models of Sequence ConsensusJournal of Computational Biology, 1995
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994
- A FUSCA gene of Arabidopsis encodes a novel protein essential for plant development.Plant Cell, 1994
- Prediction of Protein Secondary Structure at Better than 70% AccuracyJournal of Molecular Biology, 1993
- Drosophila melanogaster diphenol oxidase A2: gene structure and homology with the mouse mast-cell tum− transplantation antigen, P91AGene, 1991