A rat technique for demonstrating the interfering effect of cereals on bone calcification

Publisher Website
Google Scholar
Abstract
Anticalcifying actions of cereals similar to those previously demonstrated in dogs can also be shown in rats by employing suitable diets. It has been found possible (a) to intensify rickets by increasing the cereal intake when the other dietetic ingredients are kept constant; (b) to demonstrate great differences in the rickets-producing effects of different cereals, oatmeal being most potent and white flour least; (c) to. demonstrate the rickets-producing effect of the germ, both of wheat and maize; (d) to show the antagonism of substances containing vitamin D to the cereal action, or to lessen the effect by exposing the cereal to ultraviolet radiations; (e) to show that raising the Ca of the diet by adding CaCOs or Ca3(PO4)2 minimizes the anticalcifying action of cereals; and (f) to demonstrate the ultimate destruction of the anticalcifying action of cereals by boiling with dilute HC1.