Single‐Dose Lopinavir‐Ritonavir Acutely Inhibits Insulin‐Mediated Glucose Disposal in Healthy Volunteers
Open Access
- 1 September 2006
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 43 (5) , 658-660
- https://doi.org/10.1086/505974
Abstract
Previously, we found that 4 weeks of treatment with lopinavir-ritonavir did not decrease insulin sensitivity but did increase adiponectin levels. In the present study, a single dose of lopinavir-ritonavir decreases insulin sensitivity but does not alter adiponectin levels. Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect.Keywords
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