Current Views on the Etiology of Insulin-Dependent Diabetes Mellitus

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Abstract
THE pathogenesis of diabetes mellitus has long been an enigma. Because of its familial pattern of transmission and the subtle chronicity of the disease, diabetes has been considered a degenerative process having a genetic basis. Since degeneration means little from the perspective of etiology, and because numerous attempts at genetic analysis have failed to define a pattern of inheritance, much of what is known about the disease is descriptive.During the past decade, concepts of diabetes mellitus have been in a state of evolution as new biologic characteristics of the disease have come to light. Most workers in the field . . .