Detection of IgG and IgA antibodies to epstein-barr virus membrane antigen in sera from patients with nasopharyngeal carcinoma and from normal individuals

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Abstract
IgG and IgA antibodies to Epstein‐Barr virus (EBV) membrane antigen (MA) were detected in sera from 96 NPC patients and normal individuals by the indirect immunofluorescence test. For MA/IgG antibody, 100% of NPC patients were positive with a GMT of 1:439.7 and 97.9% of normal individuals were positive with a GMT of 1:94.7. In contrast, for MA/IgA antibody, 58.3% of NPC patients were positive with a GMT of 1:7.3 and none of the normal individuals were positive. There was no difference in the detection of antibodies to EBV MA when other P3HR‐1 or B95‐8 cell lines, differing in their major membrane antigen, were used.