Spectrophotometric determination of papaverine hydrochloride by using a membrane filter preconcentration technique with 2,4,5,7-tetrachlorofluorescein and palladium(II).

1 January 1986

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 34 (2) , 902-905
https://doi.org/10.1248/cpb.34.902

Abstract

A simple, rapid and highly sensitive spectrophotometric determination of paraverine hydrochloride (Papav. HCl) by using a preconcentration technique based on membrane filtration of the 2, 4, 5, 7-tatrachlorofluorescein (T.Cl.fl.)-palladium(II)-Papav. HCl ternary complex was developed. A linear calibration graph was obtained in the concentration range of 0-20 μg of Papav. HCl in 5 ml of dimethyl sulfoxide (DMSO). The apparent molar absorptivity for Papav. HCl was 8.0×10⁴ dm³ mol^-1 cm^-1 at 540 nm, and was more than twice that measured in an aqueous medium.

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