A Chromatographic Method for the Determination of Phenothiazine

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Abstract
A chromatographic assay of phenothiazine is described employing an acetonitrile-hexane partition system supported on Celite. Chromatographic separation is followed by ultra-violet measurement of the eluate fractions at 253 mμ. The system enables a determination of phenothiazine to be made in the presence of diphenylamine, carbazole, phenothiazone and phenothiazine sulphoxide, in addition to ingredients used as excipients in dispersible powders. The method has been tested on a range of samples and the results compared with those obtained by alternative procedures.