Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product
- 15 February 1991
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 251 (4995) , 802-804
- https://doi.org/10.1126/science.1846706
Abstract
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of 125I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF.Keywords
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