Do Drug Metabolism and Pharmacokinetic Departments Make Any Contribution to Drug Discovery?

This publication has 22 references indexed in Scilit:

• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
  Advanced Drug Delivery Reviews, 2001
• QSAR Model for Drug Human Oral Bioavailability
  Journal of Medicinal Chemistry, 2000
• Mammalian Microsomal Cytochrome P450 Monooxygenase
  Molecular Cell, 2000
• Role of pharmacokinetics in the discovery and development of indinavir
  Advanced Drug Delivery Reviews, 1999
• FDA Evaluations Using In Vitro Metabolism to Predict and Interpret In Vivo Metabolic Drug‐Drug Interactions: Impact on Labeling
  The Journal of Clinical Pharmacology, 1999
• Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
  Pharmacology & Therapeutics, 1997
• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
  Advanced Drug Delivery Reviews, 1997
• Comparison of the disposition of two novel combined thromboxane synthase inhibitors/thromboxane A₂receptor antagonists in the isolated perfused rat liver
  Xenobiotica, 1995
• A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists
  Journal of Medicinal Chemistry, 1993
• Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation
  Biochemistry, 1991