Chlorpromazine and Anesthetic Agents on Tissue Non-Protein Sulfhydryl Compounds in Normothermic and Hypothermic Rats.

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Abstract
Female rats were divided into groups and given chlorpromazine or anesthetic agents. One-half of each group was exposed to cold air in which they cooled. Total non-protein sulfhydryl concentration (NPSH) of liver and kidney was determined and compared with similar values for control animals. Chlorpromazine and all anesthetics produced a decrease in liver NPSH. Cold further decreased the NPSH of animals anesthetized with phenobarbital, thiamylal, and thiopental; but had no effect on liver NPSH of the chlorpromazine and pento-barbital groups. Ether, nitrous oxide, and phenobarbital decreased kidney NPSH. No change was observed in certain other groups. Possible relationship of anesthetics to tissue NPSH and metabolism is discussed.