REGULATION OF ANTIBODY-RESPONSE TO SRBC .1. INFLUENCE OF CORPUSCULAR AND SOLUBLE FORM OF ERYTHROCYTE ANTIGEN AND ANTIGEN DOSE ON ANTIBODY-RESPONSE IN A-J AND C57BL-10SCSN MICE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 27  (1) , 1-14
Abstract
Mice of the inbred strain C57BL/10ScSn compared to the A/J strain produce 10 times fewer IgG plaque-forming cells and serum IgG antibodies after primary and secondary SRBC [sheep erythrocyte] immunization. Even after a repeated immunization with SRBC, the titers of IgG anti-SRBC antibodies in serum do not reach the levels found in A/J mice. IgM anti-SRBC antibodies are higher in C57BL/10ScSn mice and remain high, even after repeated immunization. Antigen doses ranging from 107-1010 SRBC/mouse i.p. did not change significantly the C57BL/10ScSn mice response. Only the highest dose slightly increased IgG anti-SRBC antibody production. The use of a soluble erythrocyte antigen with similar antigenic properties as the original corpuscular form did not change the nature of IgM and IgG anti-SRBC antibody response.