The mitochondrion in apoptosis: how Pandora's box opens
Top Cited Papers
- 1 January 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 2 (1) , 67-71
- https://doi.org/10.1038/35048073
Abstract
There is widespread agreement that mitochondria have a function in apoptosis, but the mechanisms behind their involvement remain controversial. Here we suggest that opening of a multiprotein complex called the mitochondrial permeability transition pore complex is sufficient (and, usually, necessary) for triggering apoptosis.Keywords
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