New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia
- 1 June 2000
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 57 (6) , 932-942
- https://doi.org/10.1007/pl00000735
Abstract
The insulin-like growth factors (IGFs) are a ubiquitous family of growth factors, binding proteins and receptors that are involved in normal growth and development. They are also implicated in numerous pathological states, including malignancy. IGF-II is a commonly expressed growth factor in many tumors and may enhance tumor growth, acting via the overexpressed IGF-I receptor, a cell-surface tyrosine kinase receptor. The IGF-I receptor may be overexpressed due to mutations in tumor suppression gene products such as p53 and WT-1 or growth factors such as bFGF and PDGF. Thus, this family of growth factors, especially the IGF-I receptor, may present an excellent target for new therapeutic agents in the treatment of cancer and other disorders of excessive cellular proliferation.Keywords
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