DEVELOPMENT OF A BOVINE STROMA-FREE HEMOGLOBIN SOLUTION AS A BLOOD SUBSTITUTE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 157  (5) , 399-408
Abstract
A glutaraldehyde-polymerized or stabilized B-SFHS [bovine stroma free Hb solution] was developed and tested in rabbits. This solution was found to be nontoxic in terms of animal survival, nonantigenic when administered in single large volume infusions and capable of remaining in the circulation for a prolonged period of time while retaining the ability to transport and offload O2. Additionally, replacement of up to 2/3 of the blood volume with SB-SFHS [stabilized B-S FHS] was found to be advantageous over replacement with plasma protein fraction in terms of survival. By virtue of its unlimited supply, this bovine Hb solution represents a new option for a blood substitute.