Drugs Employed for the Suppression of Immunologic Responsiveness

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Abstract
SCINCE the grafting of organs between genetically nonidentical individuals uniformly leads to immunologic reaction against the graft and its subsequent death and rejection, successful homotransplantation requires immunologic modification of the recipient. At the time of writing such suppression of immunologic reactivity has been most readily obtained with drugs. It should be remarked at the outset that immunologic suppression either with drugs or by any other means is not a simple or well understood event. The complexity arises from the phenomenon of tolerance1 originally observed in neonatal animals by Medawar, but now recognized as occurring under a variety of circumstances in . . .

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