IGM MONOCLONAL PROTEIN WITH MULTIPLE SEROLOGICAL SPECIFICITIES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 37  (2) , 276-282
Abstract
An Ig[immunoglobulin]M .lambda. M-component with a false Wasserman reaction and false rheumatoid factor activity from a patient with a well-differentiated lymphocytic lymphoma is presented. The monoclonal protein showed antibody activity against cardiolipin and cross-reacted with acryl particles, not with human IgG. Both these activities were found in the Fab fragment. The reduction of the 19S IgM to 7S IgM subunits was responsible for a strong decrease in activity. The importance of the IgM quaternary structure in determining antibody affinity is emphasized.