A DNA-recombinogenic activity in human cells
- 1 January 1984
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (7) , 3057-3068
- https://doi.org/10.1093/nar/12.7.3057
Abstract
A DNA recombining protein has been partly purified from cell lines derived from patients suffering from the hereditary disease, Bloom's syndrome. The protein induces the formation of displacement loops in phi X174 RFI DNA molecules after the addition of single-stranded DNA fragments. A filter binding method and electron microscopy were used to determine the reaction. The recombinogenic protein is dependent on divalent cations and ATP for activity.Keywords
This publication has 31 references indexed in Scilit:
- Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.Proceedings of the National Academy of Sciences, 1978
- Genetic Recombination: Strand Transfer and Mismatch RepairAnnual Review of Biochemistry, 1978
- A protease inhibitor blocks SOS functions in Escherichia coli: antipain prevents lambda repressor inactivation, ultraviolet mutagenesis, and filamentous growth.Proceedings of the National Academy of Sciences, 1977
- In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stainExperimental Cell Research, 1977
- Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.1976
- An altered apurinic DNA endonuclease activity in group A and group D xeroderma pigmentosum fibroblasts.Proceedings of the National Academy of Sciences, 1976
- Uptake of homologous single-stranded fragments by superhelical DNA: a possible mechanism for initiation of genetic recombination.Proceedings of the National Academy of Sciences, 1975
- A general model for genetic recombination.Proceedings of the National Academy of Sciences, 1975
- Rapid bacteriophage sedimentation in the presence of polyethylene glycol and its application to large-scale virus purificationVirology, 1970
- Cytological Evidence for Crossing-Over in vitro in Human Lymphoid CellsScience, 1964