Endogenous pyrogen‐like substance produced by reptiles.

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Abstract
Injection of lizards (Dipsosaurus dorsalis) with rabbit [Oryctolagus cuniculus] endogenous pyrogen led to a fever. Injections with denatured endogenous pyrogen did not affect body temperature. Injection of lizards with lizard endogenous pyrogen led to a fever of short duration, while injection of denatured lizard endogenous pyrogen produced no change in body temperature. These data support the hypothesis that the febrile mechanism observed in the higher vertebrates has its origins in some primitive vertebrate.

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