Human T-Cell Leukemia Virus Type I at Age 25: A Progress Report
Open Access
- 1 June 2005
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 65 (11) , 4467-4470
- https://doi.org/10.1158/0008-5472.can-05-0559
Abstract
It has been 25 years since the discovery of human T-cell leukemia virus type I (HTLV-I) and its role in adult T-cell leukemia. Here, in brief, we review the current state of our understanding of HTLV-I epidemiology, viral biology, pathogenesis, and treatment. We discuss how HTLV-I may transform cells through destabilization of cellular genomic integrity and induction of cellular tolerance for chromosomal errors.Keywords
This publication has 51 references indexed in Scilit:
- Activating Fc Receptors Are Required for Antitumor Efficacy of the Antibodies Directed toward CD25 in a Murine Model of Adult T-Cell LeukemiaCancer Research, 2004
- Cancer genes and the pathways they controlNature Medicine, 2004
- Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitroLeukemia, 2004
- Genetic Evidence of Transmission of Human T Cell Lymphotropic Virus Type 1 between SpousesThe Journal of Infectious Diseases, 2002
- Prevalent Loss of Mitotic Spindle Checkpoint in Adult T-cell Leukemia Confers Resistance to Microtubule InhibitorsJournal of Biological Chemistry, 2002
- Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κBCytokine & Growth Factor Reviews, 2001
- Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient stateBlood, 2001
- ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESISPublished by Elsevier ,1985
- Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.Proceedings of the National Academy of Sciences, 1982
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980