Bypass specialists operate together
Open Access
- 18 February 2009
- journal article
- editorial
- Published by Wiley in The EMBO Journal
- Vol. 28 (4) , 313-314
- https://doi.org/10.1038/emboj.2008.303
Abstract
New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (pol zeta) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.Keywords
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