Phlogistic properties of the serum proteins, albumin and transferrin

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Abstract
In the experimental model for inflammation, footpad edema induced by injections of monosodium urate crystals, effects of two acute-phase reactants, the carrier proteins albumin and transferrin, were studied. Addition of small amounts of these serum components to the test system resulted in greater swelling. A dose-related response was demonstrated. Doubling the amount of transferrin produced increased inflammation. Comments are presented on the possible protective role of pertubations in the serum proteins classified as acutephase reactants in the organism's response to tissue injury or inflammation.