Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia

1 September 1985

journal article
clinical trial
Published by American Psychiatric Association Publishing in American Journal of Psychiatry

Vol. 142 (9) , 1106-1107
https://doi.org/10.1176/ajp.142.9.1106

Abstract

In a placebo-controlled single-crossover study, seven patients with treatment-resistant chronic paranoid schizophrenia who received methadone plus neuroleptic showed significant improvement. Methadone may be a useful adjunctive treatment in a subpopulation of patients with chronic paranoid schizophrenia.

Keywords

TREATMENT
NEUROLEPTICS
CROSSOVER
SUBPOPULATION
ADJUNCTIVE
SEVEN
METHADONE PLUS
PLUS NEUROLEPTIC