An Alternative Route for Preparation of α-Methylphosphonyl-β, γ-Diphosphates of Thymidine Derivatives

1 June 1994

journal article
research article
Published by Taylor & Francis in Nucleosides and Nucleotides

Vol. 13 (5) , 1031-1037
https://doi.org/10.1080/15257779408011876

Abstract

An alternative “one pot” synthesis of α-methylphosphonyl-β, γ-diphosphates of thymidine and 3′-azidothymidine is proposed. p-Toluene-sulphonic acid was used as desililating agent for triphosphate analogues.

Keywords

ALTERNATIVE ROUTE
TOLUENE
POT
ANALOGUES
TRIPHOSPHATE
AZIDOTHYMIDINE
SULPHONIC
DESILILATING
Α METHYLPHOSPHONYL

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