FACTORS GOVERNING THE RATE OF EXCRETION OF TITRATABLE ACID IN THE DOG

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Abstract
Three major factors determine the rate at which the normal kidney excretes titratable acid, namely, 1, the rate of excretion of buffer; 2, the strength of the buffer acid excreted; and 3, the extent of the depletion of the body stores of available base. The greater the excretion of buffer, the higher the pK'' of the buffer acid excreted (within a range of 4.97 to 6.8), and the lower the plasma bicarbonate concn., the greater is the rate of excretion of titratable acid. The kidney responds immediately and re-versibly to changes in these several factors. The manner in which these factors operate to govern the rate of tubular exchange of hydrogen ions for ions of fixed base is considered in the discussion.

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