Calorie Restriction and Bone Health in Young, Overweight Individuals

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Abstract
Calorie restriction (CR), a dietary intervention that is low in calories but maintains proper nutrition, is the only intervention known to consistently decrease the biologic rate of aging and increase average and maximal life span. The first randomized controlled trial of CR (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy [CALERIE]) is being conducted in nonobese men and women. In addition to testing the hypothesis that CR reduces biological aging, assessing the safety of prolonged CR on health, including bone health, is also a primary objective.