Synthesis of [18F]fluoroethoxy‐benzovesamicol, a radiotracer for cholinergic neurons
- 1 July 1993
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 33 (7) , 583-591
- https://doi.org/10.1002/jlcr.2580330704
Abstract
Full experimental details are given for the preparation of [18F]fluoroethoxy‐benzovesamicol, (−)‐(2R, 3R)‐trans‐2‐hydroxy‐3‐(4‐phenylpiperidino)‐5‐(2‐[18F]fluoroethoxy)‐1,2,3,4‐tetralin, a new fluorine‐18 labeled cholinergic neuron mapping agent for use in positron emission tomography (PET). This radiotracer was made by nucleophilic radiofluorination of tosyloxyethoxy‐benzovesamicol, followed by reverse phase HPLC purification, in decay corrected radiochemical yield exceeding 60%.Keywords
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