Plasmin Digestion of Stabilized and Non-Stabilized Fibrin Illustrated by pH-Stat Titration and Thrombelastography

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Abstract
SH-inhibitors and transamidase-inhibitors inhibit stabilization of fibrin in isolated systems, as defined by complete solubility in urea and in monochloroacetic acid. They also prolong k-values and reduce maximal amplitude in thrombelastography, but exhibit no significant effect on polymerization rate of fibrin as estimated by spectrophotometry. Stabilized and non-stabilized fibrin clots are digested at the same rate by plasmin according to pH-stat experiments. Presence of SH-inhibitors or transamidase-inhibitors enhance plasmin digestion in thrombelastographic experiments.