Measurements of the Octanol/Water Partition Coefficient by Chromatographic Methods
- 1 July 1982
- journal article
- Published by National Institute of Standards and Technology (NIST) in Journal of Research of the National Bureau of Standards
- Vol. 87 (4) , 311-315
- https://doi.org/10.6028/jres.087.020
Abstract
A theoretical relationship is developed to provide a quantitative definition of hydrophobicity using established theoretical and semi-empirical relationships. A method of predicting partition coefficients of relatively water-insoluble third components between water and an immiscible second component is devised and tested. Comparison with experimental data for four classes of compounds in the water/n-octanol system at 25 °C shows excellent agreement, indicating that values for substances for which direct determination is experimentally precluded can be calculated with confidence.Keywords
This publication has 1 reference indexed in Scilit:
- Linear Relationships between Lipophilic Character and Biological Activity of DrugsJournal of Pharmaceutical Sciences, 1972