In vitro studies on H‐2‐linked unresponsiveness to synthetic polypeptides
- 1 July 1977
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 7 (7) , 417-421
- https://doi.org/10.1002/eji.1830070703
Abstract
The in vitro production, assay and partial characterization of an extremely potent antigen‐specific T helper cell factor to poly‐L‐(Tyr, Glu)‐poly‐DL‐Ala‐poly‐L‐Lys [(T, G)‐A–L] which may be an important physiological mediator of T cell function in vivo is described. The factor has an antigen‐binding site, Ia and Ig‐like determinants on the same molecular complex. The response to (T, G)‐A‐L is under H‐2‐linked Ir gene control, some but not all low responder haplotypes will produce the factor.This publication has 6 references indexed in Scilit:
- Two genes in the major histocompatibility complex control immune responseNature, 1975
- Antigen-specific T-cell factors in the genetic control of the immune response to poly(Tyr,Glu)-polyDLAla--polyLys. Evidence for T- and B-cell defects in SJL mice.The Journal of Experimental Medicine, 1975
- Regulation of Homocytotropic Antibody Formation in the RatThe Journal of Immunology, 1974
- T cell factor which can replace T cells in vivoNature, 1974
- Specific Collaboration between T and B Lymphocytes across a Cell Impermeable Membrane in vitroNature New Biology, 1972
- Chemical Coupling of Proteins to AgaroseNature, 1967