Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy
- 1 June 1995
- journal article
- review article
- Published by Springer Nature in Immunologic Research
- Vol. 14 (2) , 132-147
- https://doi.org/10.1007/bf02918173
Abstract
A major step towards understanding the basic mechanism of systemic lupus erythematosus (SLE), the prototypic autoimmune disease that developsspontaneously, has been the identification of nucleosomes as a primary immunogen in this disease. The production of pathogenic autoantibodies in SLE results from an MHC clas-II-restricted, cognate interaction between select populations of T helper cells and B cells that are specific for nucleosomal components. These observations pave the way for specific immunotherapy that blocks this pathogenic T and B cell interaction.Keywords
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