The Leukocyte Cell Surface Receptor(s) for the iC3b Product of Complement
- 1 January 1990
- book chapter
- Published by Springer Nature
- Vol. 153, 99-122
- https://doi.org/10.1007/978-3-642-74977-3_6
Abstract
The third component of complement (C3) may be activated on a cell surface by either the classical or the alternative complement pathways and is covalently bound to the cell surface as C3b. C3b is a cofactor in the activation of the terminal compoments of C5-C9. In addition, it serves as the ligand for the type 1 complement receptor (CR1). C3b loses both of these functions when it undergoes proteolytic cleavage to iC3b and C3f by factor I. The relatively stable iC3b opsonin may then undergo proteolysis to C3c and C3dg in the presence of serum. Both iC3b and C3dg remain surface bound and are recognized by the leukocyte type 3 complement receptor (CR3) and the type 2 complement receptor (CR2), respectively. Of the surface-bound fragments of C3, iC3b is probably the most stable of the cell-associated C3 fragments and is thought to play a major role in the complement-mediated clearance of micro-organisms.Keywords
This publication has 104 references indexed in Scilit:
- Adhesive protein receptors on hematopoietic cellsImmunology Today, 1988
- Relative contribution of the leukocyte molecules MO1, LFA‐1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue‐ and stimulus‐specificJournal of Cellular Physiology, 1988
- Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA‐2 and VLA‐3 in the VLA family of heterodimersJournal of Cellular Biochemistry, 1988
- Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor .alpha.-subunits and platelet glycoprotein IIbBiochemistry, 1987
- Aggregation of complement receptors on human neutrophils in the absence of ligand.The Journal of cell biology, 1987
- Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface.Journal of Clinical Investigation, 1987
- Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta-subunit precursor and beta-subunit messenger RNA.Journal of Clinical Investigation, 1987
- Deficiency of a Granulocyte-Membrane Glycoprotein (gp150) in a Boy with Recurrent Bacterial InfectionsNew England Journal of Medicine, 1982
- Structure of vitamin D-dependent calcium-binding protein from bovine intestineNature, 1981
- Mac‐1: a macrophage differentiation antigen identified by monoclonal antibodyEuropean Journal of Immunology, 1979