A TIME-SERIES ANALYSIS OF THE INCIDENCE OF DOWN'S SYNDROME IN WEST JERUSALEM1
- 1 March 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 99 (3) , 210-217
- https://doi.org/10.1093/oxfordjournals.aje.a121604
Abstract
The age-adjusted monthly incidence of Down's syndrome has been studied in 42,340 births in 1964–1970 in the Jerusalem Perinatal Study. The overall rate was 2.4/1000 total births. There was a highly significant short-term cycle of 6 months with peaks among spring and autumn births in 6 of the 7 years studied that was independent of maternal age and standard of living. There was also a long-term decrease in Down's syndrome incidence, which may be part of a cycle of approximately 10 years. The data support the hypothesis that environmental factors play a major role in the etiology of Down's syndrome.Keywords
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