Abstract
Summary: This study aimed to assess possible fluoride uptake by cavity walls following a single application of Duraphat® around class V or I amalgam restorations which were inserted in seventeen human premolars in vitro and in vivo. Six cavities were lined with one layer of Copalite® insertion of the restorations.After a week in vivo and 12–24 h in vitro, 200–300 μm thick longitudinal sections passing through the cavities were prepared. By electron probe microanalysis F concentrations ranging from 2000 to 6000 ppm were measured near the surface of the cavity walls. Copalite seemed to inhibit F uptake. The study indicates that F ions released from the Duraphat varnish have been taken up by the cavity walls. Such uptake may influence development of secondary caries (wall lesions) in connection with amalgam restorations.