Allograft Immunity in the Mouse

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Abstract
The cellular requirements for the initiation of an allograft response in mice have been investigated with in vitro procedures for both the initiation of the response and for the measurement of the response obtained. The progenitor of the cytotoxic lymphocyte (CL) was found to be a lymphocyte of thymic origin. Various analytical cell separation and cell-mixing experiments failed to show any evidence for cooperation of this cell with another lymphocyte of either the bone marrow or thumus-dependent lineage. However, evidence was found for cooperation with a nonspecific “macrophage-like” cell. Radiation survival and analytical cell separation experiments performed to follow the development of CL after initiation indicate that they develop through proliferation and “blast transformation,” and suggest that they revert back to small lymphocytes, physically distinguishable from the original progenitors, at late times (2 to 4 weeks). Attempts to demonstrate immunologic memory in this latter population of cells were unsuccessful.

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