SELECTIVE INHIBITION BY CORTISONE OF ADRENAL CORTICAL INCORPORATION OF C14FROM LABELLED BACTERIAL POLYSACCHARIDE1,2
- 1 August 1957
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 61 (2) , 197-203
- https://doi.org/10.1210/endo-61-1-197
Abstract
In the guinea pig, the highest level of C14 derived from a labeled bacterial polysaccharide is in the adrenal cortex. The chemical nature of the C14 uptake by the adrenal is obscure but may be a significant index of "anti-inflammatory" or "glucocorticoid" activity of steroids. The adrenal incorporation of C14 is markedly depressed by cortisone, slightly depressed by 17-hydroxy-11-desoxycorticosterone but unaltered by corticosterone, 11-desoxycorticosterone, progesterone, or pregnenolone. The action of cortisone on the adrenal occurs in pre-treated animals and is prevented by concomitant administration of ACTH.Keywords
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