Carcinoma of the scrotum has been sparsely discussed in American texts and journals. This is principally a reflection of the waning incidence of the disease in this country. Nevertheless, it continues to present a formidable problem in treatment of the primary lesion and in management of advanced disease. The accompanying case report well illustrates the inevitable course which this disease may be expected to pursue in a large proportion of the cases. It further emphasizes this unique type of squamous-cell cancer of the skin. INCIDENCE In his classical monograph on carcinoma of the scrotum, Henry1 states that this entity accounts for just less than 8% of all deaths from cancer of the skin reported annually in England. It also accounts for 0.25% of all deaths from all cancers. Up to 1943, Henry had quoted 1355 cases of carcinoma of the scrotum in Great Britain. In statistical studies done in