The role of calcium in the generation of intracellular SRS‐A in passively sensitized human lung challenged with antigen

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Abstract
Summary: Calcium deprivation inhibits the formation and subsequent release of SRS‐A as well as histamine from passively sensitized human lung fragments challenged with antigen. Antimycin A inhibits the release of histamine and SRS‐A in a dose dependant fashion, while causing a mild inhibition of SRS‐A formation throughout the dose range studied. These data suggest that the influx of calcium is the critical event for the generation of SRS‐A within the cell.