Mechanisms of Contraction of the Normal and Failing Heart

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Abstract
The Sarcomere Length-Tension CurveThe Ultrastructural Basis of Starling's LawThe ultrastructural disposition of the actin and myosin myofilaments and their resultant interactions serve to explain the mechanical behavior of muscle, including the relation between muscle length and the generation of force.65 In all forms of striated muscle, including cardiac muscle, the force of contraction depends on initial muscle length (Fig. 2).68 69 70 71 72 73 74 75 76 77 78 The relation between muscle length and developed tension is similar for skeletal and heart muscle (Fig. 2), except that at the muscle length at which developed force is maximum (Lmax), the resting tension is negligible in . . .