Full-Length Genome Sequencing of HIV Type 1 Group O Viruses Isolated from a Heterosexual Transmission Cluster in Senegal
- 10 August 2001
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 17 (12) , 1211-1216
- https://doi.org/10.1089/088922201316912817
Abstract
In a polygamous marriage in Senegal, the husband and his two spouses were infected with HIV-1 group O. This study provides new full-length genome sequences for the two spouses (99SE-MP1299 and 99SE-MP1300) and the 3'-end LTR-tat fragment (6084 bp) for the husband (98SE-42HALD). Phylogenetic tree and diversity plot analysis revealed that the new viruses belong to HIV-1 group O and that they are closely related to each other in a cluster around ANT-70. The intrafamilial transmission occurred at most 6 years ago. The interpatient variability was highest in the envelope region, and in some regions of the envelope the strains from the two spouses do not cluster together anymore. The source of infection was in Cameroon and confirms a slow but continuous spread of HIV-1 group O viruses.Keywords
This publication has 15 references indexed in Scilit:
- A chimpanzee rhadinovirus sequence related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8: increased detection after HIV-1 infection in the absence of diseaseAIDS, 2000
- Sequence Note: Identification of All HIV Type 1 Group M Subtypes in Senegal, a Country with Low and Stable SeroprevalenceAIDS Research and Human Retroviruses, 2000
- Intrapatient Variability of HIV Type 1 Group O ANT70 during a 10-Year Follow-upAIDS Research and Human Retroviruses, 1999
- Phylogeny of HIV Type 1 Group O Isolates Based on env Gene SequencesAIDS Research and Human Retroviruses, 1999
- Short Communication: Molecular Characterization of the Envelope Transmembrane Glycoprotein of 13 New Human Immunodeficiency Virus Type 1 Group O Strains from Six Different African CountriesAIDS Research and Human Retroviruses, 1998
- Characterization of the Reverse Transcriptase of a Human Immunodeficiency Virus Type 1 Group O IsolateVirology, 1997
- Genetic Analysis of HIV Type 1 Group O p24gagSequences from Cameroon and Equatorial GuineaAIDS Research and Human Retroviruses, 1997
- Envelope Sequence Variability and Serologic Characterization of HIV Type 1 Group O Isolates from Equatorial GuineaAIDS Research and Human Retroviruses, 1997
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994
- A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesJournal of Molecular Evolution, 1980