Targeting sphingosine-1-phosphate for cancer therapy
Open Access
- 3 October 2006
- journal article
- review article
- Published by Springer Nature in British Journal of Cancer
- Vol. 95 (9) , 1131-1135
- https://doi.org/10.1038/sj.bjc.6603400
Abstract
This review summarises some important new findings that implicate sphingosine-1-phosphate (S1P) as a potent tumorigenic and angiogenic agent released from cancerous tumours into the tumour microenvironment. Also explored is the novel concept that bioactive lipid signalling molecules, like S1P, can themselves be targets for rational drug design, thereby opening up an entire class of lipidomic-based therapeutics for oncology and other human diseases.Keywords
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