Will Controls in Trials of Aspirin Really Avoid Aspirin?

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Abstract
To the Editor: Aspirin may be of value in arterial thrombosis.1 2 3 It has a profound effect on platelet physiology, and platelets are the primary components of such thrombi. A trial of aspirin in the secondary prevention of mortality from myocardial infarction in patients discharged after infarction has been reported from Great Britain.4 Similar studies, which are randomized and double blind, are under way in Europe and the United States. There is good reason to question their validity, for no matter how great the objectivity of the workers or the number of statisticians involved, the results are predictable. They will show . . .