Chemically Catalyzed Asymmetric Cyanohydrin Syntheses
Top Cited Papers
- 12 May 2004
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 43 (21) , 2752-2778
- https://doi.org/10.1002/anie.200300604
Abstract
Over the past two decades, significant advances have been made towards developing chemically catalyzed asymmetric cyanohydrin syntheses. Preparations that were classically highly substrate specific, often using stoichiometric quantities of reagents, have been revolutionized by a new generation of catalysts. Methods currently available rival, and in many cases surpass, enzymatic procedures in terms of synthetic utility, generic applicability, and enantioselectivity. Such protocols are increasingly finding application in the syntheses of both biologically active natural products and therapeutically important synthetic compounds.Keywords
This publication has 106 references indexed in Scilit:
- Enantioselective Total Synthesis of Epothilones A and B Using Multifunctional Asymmetric CatalysisJournal of the American Chemical Society, 2000
- Development of a family of β-amino alcohol ligands with two stereocenters for highly efficient enantioselective trimethylsilylcyanation of aldehydesChemical Communications, 2000
- Enantioselective trimethylsilylcyanation of aldehydes catalyzed by chiral lanthanoid alkoxidesJournal of the Chemical Society, Perkin Transactions 1, 1998
- A PRACTICAL SYNTHESIS OF 4-(3′,4-DIHYDROXYLPHENYL)-1,2,3,4-TETRAHYDROKOQUINOLINEOrganic Preparations and Procedures International, 1995
- Synthese und Reaktionen optisch aktiver CyanhydrineAngewandte Chemie, 1994
- Catalytic Asymmetric Cyanohydrin SynthesisSynlett, 1993
- Synthesis and Stereoselective Reactions of (R)‐α‐SulfonyloxynitrilesAngewandte Chemie International Edition in English, 1991
- Asymmetric Cyanosilylation of Aldehydes Promoted by a Novel Chiral Lewis Acid, Organoaluminum Complex of Acyclic Dipeptide Esters or α-Amino Amides Containing a Phenolic Schiff BaseSynlett, 1991
- Preparation of enantiomerically enriched compound using enzymes. Part 3. Enzymic preparation of enantiomerically enriched tertiary .alpha.-benzyloxy acid esters. Application to the synthesis of (S)-(-)-frontalinThe Journal of Organic Chemistry, 1990
- Asymmetric Hydrocyanation of Aldehydes Using Chiral Titanium ReagentsBulletin of the Chemical Society of Japan, 1988