Antigenic Characterization of Street Rabies Virus Isolates from Nigeria Using Monoclonal Antibodies1
- 12 January 1990
- journal article
- research article
- Published by Wiley in Journal of Veterinary Medicine, Series B
- Vol. 37 (1-10) , 222-228
- https://doi.org/10.1111/j.1439-0450.1990.tb01050.x
Abstract
Twenty isolates of street rabies virus were recovered in mouse neutroblastoma cells from 84 rabies suspect brain specimens from Nigeria dogs and a cat. They were characterized with the Tubingen monoclonal antibody panels directed against nucleocapsid and glycoprotein antigens. Antigenic variations were detected both with antinucleopcapsid (anti-NC) and antiglycoprotein (anti-GP) monoclonal antibodies (mabs). One isolate reacted positively with anti-NC mab P41 which hitherto has been known to react positively with polar rabies. Another isolate did not react with anti-NC mab 187.5; a reaction normally seen with ERA/SAD strains of rabies virus. With anti-GP mabs it was possible to group the isolates by their area of origin. Isolates from Plateau State were not neutralized by anti-GP mabs ERA 543 and P44.7.2. The isolates studied had glycoprotein antigenic patterns different from the pattern for low egg passage (LEP) Flury strain vaccine virus used in Nigeria for immunization of dogs.This publication has 11 references indexed in Scilit:
- Vaccination challenge studies with variants of street rabies virus isolated in NigeriaVaccine, 1988
- Rabies in vaccinated dogs: observations in eastern NigeriaRevue Scientifique et Technique de l'OIE, 1987
- Mokola virus infection in cats and a dog in ZimbabweVeterinary Record, 1983
- Clinical rabies in three vaccinated dogs in NigeriaPublished by Wiley ,1983
- EPIDEMIOLOGIC ANALYSIS OF ANTIGENIC VARIATIONS OF STREET RABIES VIRUS: DETECTION BY MONOCLONAL ANTIBODIESAmerican Journal of Epidemiology, 1983
- Atypical rabies virus in cats and a dog in ZimbabweVeterinary Record, 1982
- Antigenic variants of rabies virusComparative Immunology, Microbiology and Infectious Diseases, 1982
- Use of monoclonal antibodies in diagnosis of rabies virus infection and differentiation of rabies and rabies-related virusesJournal of Virological Methods, 1980
- Antigenic Properties of Rabies Virus ComponentsThe Journal of Immunology, 1973
- Isolation of a virus from Nigerian fruit batsTransactions of the Royal Society of Tropical Medicine and Hygiene, 1958